Cirpusins - Healthy weight, healthy heart and energy balanceCirpusins™ is the new objectivized extract developed by Sabinsa of Cyperus rotundus standardized to contain min. 6% stilbenes in the form of piceatannol, a resveratrol-like polyphenols with a considerable biological application, scirpusin A (dimer of resveratrol and piceatannol) and scirpusin B (dimer of piceatannol). Cirpusins ™ has been the subject of several studies proving its unique properties, well beyond many products on the market (simple burner or even draining). This innovative extract intervenes at several basic levels:
- Adipogenesis is a process in which pre-dipocytic cells or precursor cells proliferate and undergo differentiation to become mature adipocytes or fat storage cells, so a key therapeutic approach. Cirpusins™ showed a dose dependent reduction in adipogenesis
- Inhibition of weight gain and visceral fat : the results of the in vitro study were then confirmed in a study on an animal model at different doses along with HFD (High fat diet). The weight gain induced by HFD was significantly reduced by Cirpusins™ (61.7%), with a significant reduction (53%) in visceral fat which is often contributing to the appearance of “belly fat”.
- Normalizing effect on lipid profile, liver enzymes profile and blood sugar levels : further study of the lipid profile showed a significant decrease in all lipid parameters such as total cholesterol, low-density cholesterol and total triglycerides, and an improvement without reported side effects of the liver enzymes.
- Leptin: Since fat cells are not only fat storage cells but also have an endocrine function that decides metabolic health, a study focused on the normalization of the endocrine functions, including leptin secreted by white adipose tissue and positively correlated with the amount of body fat as a gauge for energy reserves and satiety – but their action becomes limited in case of overweight. The Cirpusins™ group showed an improvement in leptin levels, so the potential role of the combination in normalizing metabolic function and a significant advantage in overcoming leptin resistance. Similarly, a decrease in corticosteroid levels, thereby reducing the obesogenic effect of stress
Cyperus - From tradition to innovation
Cyperus is a large genus of about 700 species, throughout all continents in both tropical and temperate regions. Some specied are part of the traditional spices or used by the cosmetic industry, or as a flavoring for food. Cyperus rotundus (souchet rond, coco-grass, Java grass,...) is mentioned in traditional Chinese medicine (primary qi-regulating herb) and in the ancient Indian ayurvedic medicine Charaka Samhita (circa 100 AD). Modern ayurvedic medicine uses the plant, known as musta or musta moola churna, for fevers, digestive system disorders, dysmenorrhea, and other maladies. More recent studies have shown activity against obesity. The plant is listed in different EU lists and in BelFrIt (Rhizome, Root, Tuber).
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