MoodReal

MoodReal
Studies & Documents (11)

Crocus sativus
Safranal, Picrocrocine, Crocine
INCI:
Crocus Sativus Extract, Stigma Extract
CAS:
84604-17-1
Sectors
Food
Nutrition
Properties
Stress, Sleep, Anxiety, Depression

Download the document

MoodReal

Moodreal® - The Saffron extract that matches the science

Because of Satiereal®, Inoreal is a very important player in the saffron market - undoubtedly the leading European user for food supplements - and Saffron extracts. Based on this experience, we have developed Moodreal®, the extract that provides safranal (2%) as well as crocin and picrocrocin..Moodreal® matches exactly the extract described in studies to which all extractors refer, including those describing activity against stress and depression, by Akhondzadeh et al. (Treatment of Mild to Moderate Depression, Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression, Crocus sativus L. versus fluoxetine (ie. Prozac) in the treatment of mild to moderate depression, etc…). For example, published clinical studies confirm that:
  • The effectiveness is similar to fluoxetine (the Prozac molecule) or imipramine (a tricyclic antidepressant), without any side effects.
  • Iranian Saffron Sargol significantly relieves anxiety and depressive symptoms, at a dose of 30 mg per day and within one week.
About 10 studies have been published, especially from Akhondzadeh and al. and Noorbala and al..And in addition to those, we may confirm the efficacy specifically of Moodreal® as a SSRI (Selective Serotonin Reuptake Inhibitor) :
  • Internal study: Moodreal® showed an inhibition potency of Serotonin re-uptake equivalent to 63% of Imipra­mine, the standard SSRI used as an antidepres­sive medication and considered as the reference compound in inhibiting 100% of Serotonin reuptake. An Inhibition over 50% of Serotonin reuptake in this test that demonstrates a significant effects of SSRI.
Moodreal® is patented by Inoreal - and this original patent is indeed the one to which most of other patents are attached .Of course, Moodreal® is not offered with marketing or fancy names to name its molecules or groups of molecules, as it corresponds to the natural extract mentioned in the scientific data. It is extracted from Iranian saffron, from the Sargol vintage, with a process that preserves its active ingredients and its natural composition..Dose : 30mg of Moodreal®.EU health claims [ID 2038] : 30mg/day of extract (or the equivalent of 0,5-1g powder) : “Contributes to emotional balance”, “Helps to support relaxation”, “Helps to maintain a positive”. Other claims [ID 2247, ID 2251]

Possible EFSA Claim (for information, to be checked):[ID2038] emotional balance, relaxation, positive mood, [ID2427] libido, sperm volume, erection, [ID2251] comfort before and during menstrual cycle

Inoreal - Elimreal, Satiereal, Moodreal

INOREAL is a French company created in 2006, which helps nutrition and health manufacturers to be at the cutting edge of innovation by providing new ingredients such as Satiereal, which demonstrated their efficacy. Supported by a meticulous sourcing, exclusive extraction process, clinical studies of safety and efficacy, Inoreal®'s products are formulated to allow innovation by having the agreement of international administrations, and are allowed for selling all across the world.
They mainly supply today the Elimreal®, the Satiereal® and Moodreal®. Inoreal is a french firm.

Moodreal

Because of its other branded and patented product Satiereal®, Inoreal is a very important player in the saffron market - undoubtedly the leading European producer for food supplements - and Saffron extracts. Based on this experience and their preferred access to the Sargol vintage from Iranian saffron, Inoreal has developed Moodreal®, the extract that provides safranal (2%) as well as crocin and picrocrocin.

Moodreal® is extracted from Sargol Saffron Stigmas,
using water ethanolic process of extraction
as per the extracts described in the science and the studies

 

 

Moodreal®
a potent SRI, studied versus Imipramine

Moodreal® showed an inhibition potency of Serotonin re-uptake equivalent to 63% of Imipramine (TOFRANIL® a “golden standard” Selective Serotonin Reuptake Inhibitor (SSRI), used as antidepressive medication and considered as the reference compound in inhibiting 100% of Serotonin reuptake. An Inhibition over 50% of Serotonin reuptake in this test that  demonstrates a significant effects of SSRI.

 

 

Treatment of mild to moderate depression

Moodreal® matches exactly the extracts described in studies that most players refer to, including those describing activity against stress and depression, versus imipramine and fluoxetine (ie. Prozac®), etc….
For example, published clinical studies confirm that:

  • The effectiveness of hydroethanolic saffron extract (15mg x 2 / d saffron ext. >2% safranal) is similar to fluoxetine (Prozac®, 20mg / d) - 6 weeks, 40 adults, depression scoring >18(1)
  • In an other study (6 weeks, 30 adults, depression scoring >18), hydroethanolic saffron extract (10mg x 3 / d saffron ext. >2% safranal) is as efficient as the tricyclic antidepressant Imipramine (Tofranil®, 100 mg/d ), without any side effects (3).
  • In addition, Moodreal® showed an inhibition potency of Serotonin re-uptake equivalent to 63% of Imipramine
  • Iranian Saffron Sargol significantly relieves anxiety and depressive symptoms, at a dose of 30 mg / day and within one week (4), and again in 2019 on 57 obese adults (Depression scoring +/- 22 Beck Depression).

 

Dosing and Claims

30mg of Moodreal®

EU health claims [ID 2038] : 30mg/day of extract (or the equivalent of 0,5-1g powder) : “Contributes to emotional balance”, “Helps to support relaxation”, “Helps to maintain a positive”.

Other claims [ID 2247, ID 2251]

 

Safety

Acute Toxicity : safe LD50 > 5g/kg body weight
Mutagenicity (Ames test ) : Non mutagen
Tolerance : Well tolerated no serious undesirable events
Blood and urinary data during clinical trials:
• No change in glucose, bilirubin, leukocytes, RBCs, nitrites,
protein.
• No modification of blood cholesterol, liver enzymes, renal constants
Regulatory status: Notified to most of the EU National authorities (EU), Self affirmed GRAS acknowledge by a Lawyer (US), NPN Number (CANADA), TGA registered (AUSTRALIA).
Contraindications : None well established.

 

Before starting the extraction, the saffron goes through a set of internal controls, including botanical identification (Ph Eur), the dosage of markers (bio-actives) according to the ISO3632 standard, and the control of the total absence of addition of dyes by an analysis on each batch.

Are you interested in our solutions and want to know more?

Becarre Natural represents, distributes and develops natural actives extracts from plants for nutrition health and cosmeceutical.

Contact us