ABSTRACT Background: Tinospora cordifolia, an Indian medicinal plant, has been reported to have beneficial effects on disorders like peptic ulcer, hepatobiliary disorders, rheumatism, infectious diseases etc. It enhances cognition in normal rats and successfully overcomes cyclosporine induced memory deficit.
Methods: Thirty healthy volunteers of age 18-30 years received Tinospora cordifolia (500 mg of pure aqueous extract) or a matching placebo for 21 days in a double blind, randomized and placebo controlled design. Learning and memory was assessed by subjecting the volunteers to a battery of psychological tests that aimed at studying visual memory, logical memory, verbal memory, attention span and concen-tration.
Results: Tinospora cordifolia showed a significant (p < 0.05) increase in the test scores for ‘verbal learning and memory’ (control -1.2±1.9, drug 6.9±2.5) and ‘logical memory’ (control 5.1±6.1, drug 26.6±6.7). No significant untoward effects were reported during Tinospora cordifolia treatment.
Conclusion: Tinospora cordifolia, 500 mg daily, enhances verbal learning and memory and logical mem-ory (of immediate and short term type) compared to placebo in healthy volunteers.
Discussion (partial) : Tinospora cordifolia, used for its immu-nomodulatory effect in our study could have enhanced cognition by increasing the synthesis of IL-1 [ 14]. The second mechanism may be due to increased synthesis of acetylcholine (an important neurotransmitter in learning and memory) by the supplementation of choline, which is an important active constituent of Tinospora cordifolia. There are also reports that supplementation of choline enhances the cognitive function in animals. Further studies are needed to know the exact mechanism of action.
We believe that there is a strong need for further evaluation Tinospora cordifolia in patients with cogni-tive dysfunction. Our study has opened up a new direc-tion for future large scale clinical research to find an alternative and inexpensive drug for defective learning and memory.
Keywords: Learning, Memory, Tinospora cordifolia
Efficacy of Tinospora cordifolia on Learning and Memory in Healthy Volunteers: A Double-Blind, Randomized, Placebo Controlled Study - Iranian Journal Of Pharmacology & Therapeutics, K. Laxminarayana Bairy, Yeshwanth Rao And K. Balachander Kumar, Prodcuct supplied y Sabinsa Sami Labs

Abstract: Tinospora cordifolia is a trustfully used medicinal plant by various medicinal practices around the world. Various parts of the plant have been used in ailments such as fever, diabetes, indigestion, to name a few. e plant has a positive impact on the nervous system and enhanced memory and cognitive abilities. e present article gives an account of the plant’s pharmacological activities, particularly on memory and cognition.
Conclusion The preclinical investigations, both in vitro, and in vivo models, have demonstrated the memory and cognition improving ability of Tinospora cordifolia. The same has been demonstrated in many human studies involving healthy volunteers. The mechanism of action has been predicted to be through modulation of neurotransmitter balance, resulting in a more active and receptive brain.
Tinspora cordifolia: An Herb to Remember - Muhammed Majeed, Shaheen Majeed, Mahadeva Nayak, Naveen Yelavare Puttaswamy – Nutracos July/August 2020

ABSTRACT : It is a common misconception that ayurvedic medicines (traditional Indian system of medicine) are always safe. In fact, they also pose serious health risks either in the form of adverse reactions or in the form of drug interactions. Over 80% of our population takes ayurvedic medicines. The study was aimed to evaluate the safety profile of Tinospora cordifolia in healthy volunteers using a battery of haematological, and biochemical tests and open questionnaire method. Thirty healthy volunteers (males - 22 and females - 8) aged 18 - 30 years (mean 22.5 ± 0.28) who volunteered to participate were studied in a randomized, double - blind, placebo controlled design. The volunteers were provided with 21 days of medication (coded box) containing Tinospora cordifolia 500 mg or matching placebo. One tablet of Tinospora cordifolia of 500mg strength or placebo was taken once daily orally in the morning along with breakfast for 21 days. The safety assessment was done with the help of haematological and biochemical investigations which were assessed before and after the medication by unpaired t test. ‘Unpaired t test’ using SPSS computer software package. Analysis of the various lab values between the control and the test group before and after taking the drug/placebo by unpaired ‘t’ test shows no significant difference between the groups (p = > 0.05).Hence it can be concluded that Tinospora cordifolia is safe at a dose of 500mg per day for a period 21 days in healthy volunteers for the parameters studied.
Keywords: Healthy volunteers, safety, Tinospora cordifolia
Safety of Aqueous Extract of Tinospora cordifolia (Tc) in Healthy Volunteers: A Double Blind Randomised Placebo Controlled Study - IRANIAN JOURNAL OF PHARMACOLOGY & THERAPEUTICS - 1735-2657/07/61-59-61
Product supplied by Sabinsa Sami Labs

Tinospora cordifolia is one of the extremely valued medicinal plants of Ayurveda. It is commonly called as “Guduchi”. Guduchi in Sanskrit means one which protects the entire body and is attributed to its ability to impart youthfulness, vitality, and longevity. In Ayurveda, Tinospora cordifolia is believed to have rejuvenating, tonic, anti-aging, longevity and aphrodisiac properties. Traditionally well known for its anti-stress activity. The plant has been validated for its anti-inflammatory, anti-diabetic, anti-arthritic, anti-stress, anti-allergic, anti-malarial, immunomodulatory and hepato-protective activities.
Tinofolin® was evaluated for its ability to improve visual memory, logical memory, verbal memory, attention span and concentration in a placebo-controlled double-blind study involving 30 human volunteers of age 18-30 years for 21 days. The supplementation (500 mg/day) significantly improved verbal learning (placebo: -1.2±1.9 / Tinofolin®: 6.9±2.5; p max 0.05) and memory and logical memory (placebo: 5.1±6.1 / Tinofolin®: 26.6±6.7; p max 0.05) compared to control. There were no significant untoward effects reported during the trial. Hence, Tinofolin® at 500 mg per day enhances the verbal learning and memory and logical memory (of immediate and short term type) compared to placebo in healthy volunteers (Bairy et al., 2004).
In another double-blind placebo-controlled study in 30 healthy human volunteers for 21 days, 500 mg of Tinofolin® showed no change in the hematological and biochemical parameters. Hence, Tinofolin® can be considered as safe for human consumption (Karkal and Bairy 2006).