Background: Both intrinsic and environmental factors play a role in premature ageing of the skin. Natural extracts have been extensively used to reduce the signs of ageing in recent years. Pterostilbene is a natural analog of resveratrol with therapeutic properties against numerous diseases mainly due to its ability to reduce reactive oxygen species.
Methods: We studied the anti-aging and skin brightening effect of a 0.4% formulation of natural pterostilbene in healthy volunteers (N=38) in an open-label, single-arm, monocentric study for 8 weeks. The melanogenesis inhibitory, anti-tyrosinase and anti-collagenase and anti-elastase properties of pterostilbene were evaluated in vitro.
Results: Natural pterostilbene showed significant inhibition of melanogenesis in vitro. Pterostilbene cream (0.4%) was highly effective in reducing markers of aging and induces even skin tone. The product was effective in reducing wrinkles and fine lines, improved skin hydration elasticity and showed no adverse effects.
Conclusion: Our results suggest that natural pterostilbene is a safe and effective ingredient for use in cosmetic preparation to reduce the markers of skin ageing and brighten the skin tone.
The results of the study described herein suggest that Natural pterostilbene is a safe and effective molecule for skin brightening and reducing signs of aging. These findings could potentially be applied in various other formulations of skincare products that help reduce photoaging, UV damage, skin brightening, and even toning.With the increasing demand for the natural cosmetic requirement by the consumers, pterostilbene offers a natural alternative for cosmetic formulations to prevent deteriorative changes during skin aging and keep the skin glowing and healthy.
Trial Registration: Clinical Trial Registration India Identifier CTRI/2019/01/017160 [Registered on 18/01/2019].
Keywords: natural pterostilbene, Pterocarpus marsupium, skin brightening, antiaging
Study for PteroWhite 90%
An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects Muhammed Majeed, Shaheen Majeed, Renuka Jain, Lakshmi Mundkur, HR Rajalakshmi, Prachi Subhash Lad, Prakriti Neupane - Clinical, Cosmetic and Investigational Dermatology 2020:13 105–11

Abstract: Ultraviolet (UV) rays and its harmful effects have always been a concern to skin health. Sunscreen and sunblock prevent the harmful effects of UV radiation on the skin. Sun Protection Factor (SPF) is an indication of the sun-protective capacity of an ingredient. There is an ever increasing interest in the cosmetic industry for developing novel functional ingredients from natural sources. The purpose of this study was to determine in-vitro and in vivo SPF of natural 90% pterostilbene extracted from the dried heartwood of Pterocarpus marsupium (Indian Kino). The SPF of purified pterostilbene and a formulation containing 0.4% pterostilbene was determined In Vitro using a UV spectrophotometer. Pterostilbene had an SPF of 21.73 +- 0.06, while the cream formulation had an SPF of 8.84 +- 0.01. The in vivo SPF of the 0.4% pterostilbene cream in humans was found to be 6.2 1.30. Primary skin irritation tests in human subjects showed the formulation was safe and had no irritation potential. Pterostilbene was also found to have significant antioxidant activity as determined by free radical scavenging assays in vitro. These results suggest that natural pterostilbene is an antioxidant and shows SPF value both in-vitro and in the human clinical study and thus could be used as an ingredient in topical sun-protective formulations.
UV radiation causes skin damage and there is an urgent need to protect from its harmful effects. Natural ingredients usually have the potential to protect against the toxic effects of UV radiation. Natural pterostilbene has shown its potential as a safe and effective ingredient in topical formulations for sunscreens and UV protection. The product may be used in combination with other ingredients to boost the SPF value of sunscreen formulations. Further research is required in the development of new effcacious and safe plant-based natural ingredients and formulations which are effective in protecting skin from harmful radiations.
Keywords: Pterostilbene; PteroWhite®; sun protection factor; SPF; sunscreen application; sun UV protection; in vitro; in vivo; ISO 24444 method; minimal erythema dose
Study for PteroWhite 90%
A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from Pterocarpus Marsupium - Muhammed Majeed, Shaheen Majeed, Renuka Jain, Lakshmi Mundkur, H. R. Rajalakshmi, Prachi Lad and Prakriti Neupane - Cosmetics 2020, 7, 16

Sun Protection Factor of Natural Pterostilbene from Pterocarpus Marsupium
The anti-aging and skin brightening effect of pTeroWhite® (Pterocarpus marsupium extract – natural pterostilbene 90%) cream was demonstrated in an open-label, single-arm, monocentric efficacy study in 38 healthy volunteers who applied a cream containing 0.4% pterostilbene for a period of 8 weeks [1]. The dermatological assessment, together with instrumental and image analysis suggests that pTeroWhite effectively improves skin brightness, elasticity, reduces the appearance of fine lines, wrinkles, and improves skin texture as compared to baseline in the subjects studied. A positive change was observed at all time points in skin hydration and elasticity in both male and female subjects with regular usage of the pTeroWhite cream. Significant improvement was observed in under-eye fine lines at all-time points and in wrinkles, frown lines, and crow’s feet area at the end of the study. pTeroWhite was able to improve the skin luminosity with continuous application. All the study subjects agreed that the test product makes their skin moisturized, brighter, younger, firmer, and make their skin look even toned. Further, no product-related skin irritation, intolerance, or adverse event recorded during the study. The study concluded that application of pTeroWhite cream twice daily for 8 weeks was safe, and improved skin texture tone, and helps in keeping skin moisturized, supple and young. The study can be accessed at https://doi.org/10.2147/CCID.S238358
 
Sun Protection Factor of Natural Pterostilbene from Pterocarpus Marsupium
In another clinical study, the effect of pTeroWhite as a natural SPF ingredient was demonstrated [2]. A cream formulation containing 0.4% of pTeroWhite was evaluated in 12 healthy volunteers, as per the ISO 24444:2010 regulations, resulting in a SPF value of 6.2 ±1.30. The cream was found to be safe and non-irritant in a repeated patch test conducted on 25 healthy individuals, prior to the SPF study. The cream showed an SPF of 8.84 ±0.01, in vitro, while pTeroWhite as an ingredient had an SPF value of 21.73 ±0.06. Further, the study demonstrated the potent antioxidant effects of pTeroWhite in the various in vitro and cellular test systems. With the current status of chemical sunscreens, and the concerns about their systemic absorption and safety, this study has demonstrated pTeroWhite asa safe alternative in topical sun-protective formulations. Further details of the study could be accessed at https://www.mdpi.com/2079-9284/7/1/16
Study for PteroWhite 90% [SBPTERWHIT]