Studies & Documents (8)
News (4)

Bacillus coagulans
200 AU/ml, 1% Protein
Bacillus Ferment Filtrate Extract
Acne, Antimicrobial, Preservative
Hair, Nails
Oral care
Skin integrity, Inflammation, Healing

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Lactosporin® - The new Post-Biotic, Skin (Acne), Hair, Oral care

Source: Bacillius / Inci : Bacillus Ferment Filtrate Extract / Antimicrobial activity : nlt 200 AU / ml against Micrococcus luteus / Protein : nlt 1.0 w/v (Lowry’s Method) / Dosage : recommended 0.5% w/w.Pale yellow to brown color clear to hazy liquid with characteristic odor, It is an ingredient for cosmeceutical products that has antimicrobial, antioxidant, anti-inflammatory, and anti-collagenase properties, shows protective efficacy against UV radiation, environmental pollutants, and prevents microbial biofilm formation, induces hair growth, and prevents accelerated skin aging – so diverse exciting applications of LactoSporin.
  • Skin care : antiacne, showed potent antioxidant, anti-inflammatory, anti-collagenase and UV protection potential, thus playing a protective role to the skin
  • Hair Care : stimulated the anagen phase of follicular cell growth by increasing the proliferation of dermal papilla cells and by inhibiting 5a-reductase activity.
  • Oral Care : significant reduction (for about 12 hours) in the growth, rate of pH drop (prevention from detrimental acidic environment) and glucan production was observed in S. mutans within 5 minutes of the LactoSporin A study has been published in 2018 by an external organism on action against Gardnerella vaginalis : “Mode of action and safety of lactosporin, a novel antimicrobial protein produced by Bacillus coagulans ATCC 7050”. It says as conclusion : “Lactosporin potentially exerts its antimicrobial activity by selective dissipation of ΔpH and/or by causing leakage of ions from the sensitive cells. Safety studies suggest that lactosporin is a non-cytotoxix antimicrobial for vaginal application”
  • A new study published in end of 2020 : "Novel Topical Application of a Postbiotic, LactoSporin®, in Mild to Moderate Acne: A Randomized, Comparative Clinical Study to Evaluate its Effcacy, Tolerability and Safety"
The therapy for mild-to-moderate acne includes topical antibiotics, benzoyl peroxide and retinoids. Here, the effcacy of LactoSporin® 2% w/w cream was compared with with benzoyl peroxide in 64 male and female subjects with mild-to-moderate acne for three weeks. The effcacy parameters were evaluated based on the dermatologist visual assessment and instrumental measurements using Sebumeters and questionnaires. Adverse events were recorded throughout the study period. Also : pH stability, thermostability, antimicrobial activity and 5-alpha reductase activity. A very significant improvement in the dermatological assessment of closed comedones (p below 0.0001), open comedones (p = 0.0069) and papules count (p below 0.0001) in comparison to the baseline in both LactoSporin and benzoyl peroxide groups. The antera analysis showed significant improvement in redness (p below 0.0001) and elevation (p below 0.0001) (small and medium) in both the treatment groups. The sebumeter analysis showed a significant decrease in sebaceous secretion (p below 0.0001) for LactoSporin, which resulted in reduced oiliness, pimples, acne spots and redness around the acne spot. The product was found to be safe without any irritancy. LactoSporin was stable at an acidic pH and temperature range of 70 to 90°C, with antimicrobial activity against various pathogenic bacteria, including Cutibacterium acnes. It was also a potent inhibitor of 5-alpha reductase activity. Thus, it can be concluded that the effcacy of LactoSporin is equivalent to benzoyl peroxide in the treatment of mild-to-moderate acne lesions and better than benzoyl peroxide for reducing the sebaceous secretion and oily, greasy nature of the skin, implying its effcacy in other sebohorriec conditions.
  • " Skin Protective Activity of LactoSporin-the Extracellular Metabolite from Bacillus coagulans MTCC 5856"
LactoSporin has shown antioxidant activity and has been shown to protect skin cells from UV-induced apoptosis. It inhibited collagenase, elastase, and hyaluronidase activity and upregulated expression of hyaluronan synthase, which are associated with the integrity of the extracellular matrix.

Probiotic / postbiotic - Living or revivable micro-organisms (pro-), or food substances (pre-) with beneficial effects

The intestinal flora, or microbiota, is composed of many bacteria for a crucial role:
  • Barrier to pathogens (actions on sites)
  • Interacts with the intestinal immune system.
  • Facilitates the transformation of nutrients, as well as the elimination of certain toxic substances ...
Probiotics are living microorganisms. By rebalancing the intestinal flora, they help in particular in the digestion of fibers, stimulate the immune system and regulate transit ....Postbiotics refer to soluble factors (products or metabolites), secreted by living bacteria, or released after bacterial lysis: signaling molecules with anti-inflammatory, immunomodulatory, anti-obesogenic, antihypertensive, hypocholesterolemia, antiproliferative and antioxidant activities .

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