Licorice CG
Licorice CG
Glabridine - Inhibition of the production of active oxygen species and of tyrosinase (Whitening / lightening)
Glabridin may inhibit melanogenesis by one of two mechanisms:
Inhibition of the production of active oxygen species
Inhibition of tyrosine: Human tyrosinase is an essential enzyme, which regulates the production of melanin, a group of brown to black pigments in the skin and eyes of humans.
It is a known fact that a number of reactions (e.g. inflammatory, etc.) are induced when human skin is exposed to UV radiation. The membrane phospholipids of the skin tissue are damaged by UV-induced active oxygen. Histological changes occur in the skin that manifest as erythemas and skin pigmentation. Active oxygen is one of the species that induces skin pigmentation. Thus, prevention of its production is linked to .
An assay was performed to test the activity of glabridin when used for topical application. UVB-induced pigmented skins of guinea pigs were treated with glabridin solution/
Licorice used topically is documented to reduce the amount of corticosteroids in dermatological infections. This is probably by inhibiting 11 - beta hydroxysteroid dehydrogenase which is responsible for the conversion of cortisol to corticosterone and thus, potentiating the effects of steroids.
Profile of licorice root extract with 4% Glabridin
INCI: Bleaching : Lighten shades of hair and complexion
Licorice - Various natural actives in Licorice
Liquorice (Glycyrrhiza glabra) or licorice is also Known as Madhuka or Yashti-madhu in Ayurveda. The root of Glycyrrhiza glabra is known for its ability to impart sweet taste to various formulations. Licorice extract is useful in digestive and oral care applications. It has been traditionally used for it cough suppressant activity, anti inflammatory (tooth paste, mouth washes), digestive candies and arterial pressure pending on the type of extracts.
Licorice leads to many products extracted from the root: sweetener (glycyrrhizin salt, especially mono ammonium), anti-inflammatory and anti-ulcer (GLA-18 beta, enoxolone, carbenoxolone), whiteners / glow (glabridin), aid in digestion and against ulcers, anti-asthma, treatment of fevers and colds.
Glycyrrhizic acid (= glycyrrhizinic acid, = glycyrrhizin) is an active substance (saponin) in licorice. It is a heteroside, poorly soluble in water, mainly known for its sweet taste, hence its use as a sweetener. Glycyrrhizin can cause high blood pressure by inhibiting an enzyme, reason why some products are guaranteed to be low in glycyrrhizic acid.
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