Coleus 10% Organic

Studies & Documents (1)

Coleus forskohlii

10% Forskolin

INCI:

Coleus forskohlii (root) extract, Plectranthus barbatu

CAS:

223748-52-5

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Coleus 10% Organic

Coleus - Stimulation of adenylate cyclase with Forskholin

Coleus Forskholii root extract standardized from 10% Forskholin (oral grade) to 98% Forskholin (cosmetic grade).
Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP.
It is used in nutrition (slimming : Promoting lean body mass) as well as in cosmetics or in nutracosmetic for its action of reducing subcutaneous fat mass and skin conditioning agent.

Possible EFSA Claim (for information, to be checked): [ID2248] Weight management, fat destorage

Coleus - Coleus, Plectranthus barbatus or Indian Coleus, source of forskolin and decanal

Coleus forskohlii (or Plectranthus barbatus) commonly known as Coleus of India, grows in the mountains of Asia, and more particularly in the tropics and subtropials of Southeast Asia. Used for millennia in Ayurvedic medicine, Coleus forskohlii was then used to treat cardiovascular, respiratory (asthma), ophthalmological and skin disorders.
Used for millennia in Ayurvedic medicine, Coleus forskohlii was then used to treat cardiovascular, respiratory (asthma), ophthalmological and skin disorders.
Coleus forskihlii is the only known plant source of forskolin, a natural compound which gives it its slimming properties and protects the skin. This diterpene is a non-adrenergic stimulator of adenylate cyclase, an enzyme that plays a role in thermogenesis and the use of fat cells for energy. It’s also why it’s used in anti-cellulite cream and – indirectly – for tanning. About the Coleus oil, it was found to more effectively inhibit the growth of skin pathogens than the well known tea tree oil as well as Lavender oil, and Bergamot oil. It was found to be equivalent to Clindamycin.
The primary mode of action of forskolin is to increase cellular concentrations of functions mediated by cyclic AMP (cAMP), via activation of the enzyme Adelylate cyclase (referred as the "second messenger"). Cyclic AMP facilitates the action of "primary messengers" or various hormonal and bioactive substances in the body (such as insulin). By facilitating hormonal action, cyclic AMP can help increase metabolic rate and thermogenesis. These events correspond to the accumulation of lean mass. Typically, an increase in cyclic AMP leads to subsequent activation of protein kinase. Protein kinase has been shown to activate hormone-sensitive lipase that is involved in the breakdown of triglycerides, known as the building blocks of fatty tissue. These events correspond to the decrease in body fat.

Studies & Documents(1)

Plectranthus (Coleus) : A review of ethnobotanical uses

[From Litterature]

Plectranthus, also named Coleus..

Plectranthus is a large and widespread genus with a diversity of ethnobotanical uses. The genus is plagued with numerous nomenclatural disharmonies that make it difficult to collate accurate data on the uses. The aim of this review is to gather together all ethnobotanical information on Plectranthus and to map the data onto the most up-to-date phylogenetic classification in order to see if there are similar uses among related species and hence provide a framework for the prediction and exploration of new uses of species.
The uses of 62 species of Plectranthus were mapped onto a current phylogeny based on DNA sequence data. The phylogeny reveals two major Clades, 1 and 2. The members of Clade 1 (corresponding to the formally recognized genus Coleus) were richer in number and diversity of uses than members of Clade 2 (comprising the remaining species of Plectranthus). The high incidence of synonymy can lead to problems in uncovering a species’ ethnobotanical profile. About 30% of all citations of Plectranthus use a synonym and most of the synonyms are attributed to 10 of the most used species, 9 of which are in Clade 1.
Members of the ‘Coleus’ Clade are the most studied group both taxonomically and economically. The higher incidence of study may be as a result of the higher diversity of uses and the fact that species in Clade 1, such as Plectranthus barbatus, Plectranthus amboinicus and Plectranthus mollis, are geographically more widespread than those in Clade 2.
Plectranthus species in Clade 1 are frequently used as medicines and are used to treat a range of ailments, particularly digestive, skin, infective and respiratory problems. Plectranthus used as foods, flavours, fodder and materials are also mostly found in Clade 1.
Monoterpenoids, sesquiterpenoids, diterpenoids and phenolics have been reported in species of Plectranthus. The abietane diterpenoids are the most diverse of the diterpenoids isolated from species of Plectranthus. The labdane diterpenoid, forskolin, occurs in Plectranthus barbatus and could explain some of the traditional uses of this species. This review highlights the fact that not enough is known about the chemistry of other species of Plectranthus to explain their traditional uses.
Plectranthus: A review of ethnobotanical uses - Catherine W. Lukhoba, Monique S.J. Simmonds, Alan J. Paton - Journal of Ethnopharmacology 103 (2006) 1–24

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Becarre Natural represents, distributes and develops natural actives extracts from plants for nutrition health and cosmeceutical.

Coleus 10% Organic

Coleus 10% Organic

Coleus - Stimulation of adenylate cyclase with Forskholin

Coleus - Coleus, Plectranthus barbatus or Indian Coleus, source of forskolin and decanal

Plectranthus (Coleus) : A review of ethnobotanical uses

Are you interested in our solutions and want to know more?

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