Ingredient, Study, Innovation

Study with Vanizem is now published

Study with Vanizem is now published

The in-vivo study on Vanizem is now published. It confirms the potential of the Vanizem (A. melegueta extract) for anxiety reduction, mood improvement, stress mitigation, and sleep enhancement, at doses ranging from 50 to 150 mg, with no reported side effects.

Vanizem™ is the very innovative and fast-acting, non-sedative botanical extract that supports positive mood and provides effective management of day-to-day stress. It has also shown to lower tension, reduce perception of anxiety and elevate mood within just three days.

  • Clinically studied
  • 100-150 mg/day dose
  • Efficacy starting within 3 days
  • Unique mechanism of action
  • Standardized to ≥ 10% total vanilloids and ≥ 1.5% 6-paradol
  • Sustainable, cultivated raw materials
  
  • Promotes mental wellbeing
  • Lifts Mood
  • Reduces Tension
  • Lower perception of day-to-day stress
  • Supports feelings of calmness
  • Improves Sleep Quality
  • Non-sedative
  • Targets endocannabinoid system
  • Fast acting effects
  

Vanizem™ is derived from sustained cultivated sourced Aframomum melegueta of West African origin and uses Nektium’s proprietary extraction and bioactive standardization

Aframomum melegueta seeds are known as the spice for cooking, especially from West African, but also in EU and US. It is a Zingiberaceae (ginger family), meaning ‘chili pepper’ in Portuguese. Maniguette – the name in French - was one of the main export commodities from the West African coast from the 14th century, and gave its name to the Pepper Coast in the Gulf of Guinea. The species has also been introduced to the Caribbean (Martinique and Trinidad and Tobago) and South America (French Guiana and Guyana).

Also known as Grains of Paradise, besides the use as a spice for seasoning food, it has also been used for treating many digestive system issues among others.

 

Study - published (2025)

This in-vivo study supports the potential of the Vanizem (A. melegueta extract) for anxiety reduction, mood improvement, stress mitigation, and sleep enhancement, at doses ranging from 50 to 150 mg, with no reported side effects.
Aframomum melegueta Seed Extract’s Effects on Anxiety, Stress, Mood, and Sleep: A Randomized, Double-Blind, Pilot Clinical Trial, Rubén Pérez-Machín, Tanausú Vega-Morales, Carlos Elvira-Aranda, Loreto Lledó-Rico, María José Gomis-Gomis and Laura López-Ríos - Pharmaceuticals 2025, 18, 278

 

A set of validated psychometric test questionnaires was collected before and 48h after the first intake. A. melegueta extract interaction with canonical endocannabinoid receptors (hCB1R and hCB2R), the serotonin receptor (5HT1AR) and gamma-aminobutyric acid receptor (GABAA1R) was evaluated by the radioligand binding assay. Additionally, receptor functional assays and enzyme inhibition assays were conducted to test the extract’s functional activity on the non-canonical endocannabinoid receptor (TRPV1) and the cannabinoid fatty-acid amide hydrolase enzyme (FAAH), respectively.

 

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