Nootropic effect of Zynamite® in publication
In the first study MLE improved all scores for Profile of Mood States (POMS), with the score for “fatigue” significantly improved.
The latest published article “Central Nervous System activities of extract Mangifera indica L. outlines the nootropic effect of Zynamite® based on the studies that Nektium has performed.
- Mangiferin was found for the first time to be a catecho-O-methyltransferase inhibitor
- Mangiferin and Mangifera indica extract (MLE Zynamite) for the first time have been shown to increase long-term potentiation in vitro in a hippocampus slice model
- Mangiferin and MLE have shown to cause a similar pattern of change in EEG in vivo
In pilot translational RTC clinical trials MLE: change the pattern of brain electrical activity significantly during cognitive challenges / improved reaction time / improved score of fatigue / was well tolerated
https://doi.org/10.1016/j.jep.2020.112996
- Mangiferin is a COMT inhibitor of moderate potency and is the major CNS-active compound in MLE. Both mangiferin and MLE increase hippocampal LTP in-vitro, and induce a similar pattern of changes in brain electrical activity in-vivo.
- While the translational clinical trials of MLE are limited by being single dose studies in a small number of subjects, they provide the first clinical evidence that the extract is well tolerated with no cardiovascular side-effects, can induce changes in brain electrical activity, may give a faster reaction time, and decrease fatigue.
- These CNS activities support the reported folk-uses use of mango leaf tea as a substitute for tea and as a traditional remedy for fatigue and exhaustion. Extract Mangifera indica L., Zynamite, has nootropic potential, and larger clinical studies are needed to realise this potential.