Pomegranate provides Ellagic acid ... and so much more!

Becarre natural

Becarre offers different grades of pomegranate extract from Nektium or Sabinsa, based on bioactives compounds as punicosides and punicalagins A+B (strong antioxidant), and other polyphenols, carrier free, from mashed fruits. The Pomegranate seed oil is more dedicated to body weight thanks to the Punicic acid, fatty CLNA. And the standardized grades at 40% up to 98% Ellagic acid.

Becarre Natural


HPLC profile of Pomegranate P40P with punicalagins

Fig.1 - HPLC profile of Pomegranate P40P



Becarre Natural

Becarre Natural

Becarre presently offer different grades extracted from pomegranate :

Becarre NaturalPomegranate P40P from Nektium brings bioactives compounds as punicosides and punicalagins A+B (strong antioxidant), and other polyphenols, carrier free : cardiovascular, antioxidant. Also some research on prostate health and joints

Becarre NaturalPomegranate seed oil from Nektium is more for body weight - also used in their patented Xanthigen – and antioxidant, contains Punicic acid, fatty CLNA

Becarre NaturalPomegranate Ellagic from Sabinsa brings 40% Ellagic up to 98% ellagic acid. A study has been conducted on the skin lightening properties using oral ellagic acid

Becarre NaturalPomegranate POE from Nektium brings 40% Ellagic acid but not only since it also provides other polyphenols found in pomegranates, namely punicalagins a and b.

Pomegranate P40P

P40p™ is a unique product, carrier free, soluble in water and is standardized to a full spectrum of all of the essential compounds responsible for specific health promoting benefits of pomegranate juice, manufactured under strict GMP procedures. The P40p™ extract is standardized to 40% punicosides with a minimum concentration of 30% punicalagins. Additionally, P40p™ guarantees a total polyphenol content of no less than 50% (Table 1). The final product is free of yeast and bacterial contamination, allergens, gluten, BSE, GMO and irradiated products. P40p™ is Kosher certified and suitable for vegans. Approximately, 30 mg of P40pTM provides an equivalent amount of bioactives than 50 ml of pomegranate juice.

Chemical Profile

The key bioactive compounds in pomegranate fruit are a group of hydrolizable ellagitanins generically called punicosides, including punicalins, punicalagins (A+B), ellagic acid glycoside and ellagic acid. Ellagic acid is commonly used to standardize commercial pomegranate extracts but this approach is unreliable, potentially misleading and vulnerable to adulteration (Zhang, 2009). Punicalagins have been identified as being responsible for most of the antioxidant activity present in the pomegranate fruit (Gil, 2000) and represent a more reliable means of standardization of commercially produced pomegranate extracts (Jimenez Del Rio, 2006). Animal studies have shown that both ellagic acid and punicalagins are absorbed by the gastrointestinal track after oral ingestion of pomegranate juice or extract, with the concentration of the latter being higher. Punicalagins are not absorbed in vivo directly but reach the colon and release EA that is metabolised by the human microflora (Larrosa, 2006).

Cardiovascular Health

Atherosclerosis is a collection of patchy plaques (called atheromas) in medium-sized and large arteries. These plaques contain lipids, inflammatory cells, smooth muscle cells, and connective tissue. Several investigators have studied the influence on cardiovascular health of pomegranate supplementation. They have measured how pomegranate affects several markers involved in the development of atherosclerosis, such as plasma lipid profiles, lipid- oxidation status, platelet a ggregation, interaction between macrophages lipids, and stress to the arterial wall. More recently Rosemblat has also confirmed that pomegranate juice daily consumption improves plasma lipid oxidant profile in patients with diabetes by reducing lipid peroxide and cellular peroxides and increasing glutathione levels, factors that all contribute to development of atherosclerosis in these patients (Rosemblat, 2006).

Cancer

Cancer is an unregulated proliferation of cells which lose their normal controls, resulting in unregulated growth, lack of differentiation, local tissue invasion, and, often, metastasis. Dozens of information (angiogenesis, apoptosis, cells differentiation and signaling) gathered on cellular cultures and animal models have been collected. Pantuck et al found that daily supplementation with pomegranate juice (PJ) led to a significant decrease in tumor progression in patients with prostate cancer that had undergone surgery or radiotherapy. They were able also to confirm in in vitro investigations that PJ induced apoptosis and decreased cell proliferation (Pantuck, 2006).

Pomegranate Seed Oil [PSO]

Pomegranate seed oil (PSO) is rich in Punic Acid (PA) and contains other actives such as ellagic acid, other fatty acids and sterols (Schubert, 1999; Amakura, 2000; Abd El Wahab, 1999). Nektium manufactures PSO with at least 80% content of PA.

Punicic acid

Punicic Acid (PA) is structurally related to Conjugated Linolenic Acid (CLNA), and their potential beneficial biological effects (for instance significant decrease in hepatic tryacylglycerol deposits, as well as levels of monounsaturated fatty acids). In fact PA has been found in animal models to accumulate in liver and perirenal fat, increasing serum levels of tryacylglycerol and phospholipids, which suggest PA mobilizes fat out of their storage sites into the blood (Yamasaki, 2006), corroborated later on in ICR CD-1 mice. At the molecular level, investigators have found that PA activates a class of receptors (PPARγ) also activated by oral antidiabetic agents, which in principle could play an important role in glucose homeostasis and obesity related inflammation. In summary, PSO has shown beneficial effects on the lipid storage and lipid serum profile in obesity animal models with a strong suggestion that it may also help uncontrolled blood glucose levels.

Pomegranate Seed Oil in Xanthigen™

Xanthigen™ is a nutraceutical combination product intended for weight management, partly based on Nektium’s PSO. In a clinical trial, investigators found that PSO acted synergistically with a fucoxanthin, increasing the resting energy expenditure (REE). Increase in REE leads to losing weight (Abidov, 2010). More recently, investigators have reported that PSO can down- regulate the expression of adipogenic genes (PPARγ) in fat cells.

Oral Administration of Ellagic Acid for skin lightening

Ellagic acid is used in topical formulation for its lightening effect on UV induced hyperpigmentation. It’s know that Ellagic inhibits melanin formation by acting on tyrosinase.

Oral administration of ellagic acid (alcoholic extraction followed by acid hydrolysis) has been studied, and its metabolites have been detected in urines and feces. A whitening effect on UV-induced pigmentation was observed, with a reduction on the number of DOPA-positive melanocytes (Mineka Yoshimura, 2006).
A double blind vs placebo clinical trials has evaluated the protective and ameliorative effect at 200mg and 100mg of ellagic acid per day, orally, followed by UV radiations. It’s so suggested that Ellagic acid orally administrated is absorbed into the body and the ellagic and/or its metabolites inhibits the proliferation of melanocytes in the skin. Those studies have been performed in Japan, with products offered by Sabinsa Japan Corp.
Effects or Oral Administration of Ellagic Acid-rich pomegranate Extracts on UV induced pigmentation in the human skin, Kouichi Kasai, Mineka Yoshimura, Takuro Koga, Masayuki Arii, Satoru Kawasaki, J Nutr Sci Vitaminol 52, March 2006
Inhibitory Effect of an Ellagic Acid-rich Pomegranate Extract on Tyrosinase Activity and UV- Indudex pigmentation, Mineka Yoshimura, Yuko Tanabe, Kouichi Kasai, Yuan Yamakoshi, Taguro Koga, Biosci. Biotechnol. Biochem 69, 2005


Gontran Gaillot