Thanks to its gliadin matrix acting as the vehicle, GliSODin® is the first orally effective SOD supplements

Becarre natural

GliSODin® is the radical new natural and oral approach for skin health, immune health and to fight oxidative stress and free radicals. GliSODin® is developed by Isocell and supported by more than 20 – mostly published - studies.

Becarre Natural
Becarre Natural


Causes of cell stress

Fig.1 - Causes of cell stress



Cascades of reactions

Fig. 2 - cascades related to SOD



Antioxidant

Fig.3 - Powerfull antioxidants



oral administration of GliSODin compare to standard SOD

Fig. 4 Activity after oral administration



SOD activity after ingestion compare to initial activity

Fig.5 - SOD Activity vs. initial



There is also a focus-on dedicated to the studies performed using GliSODin.

Production of reactive oxygen species (ROS) is a normal process in oxygen-breathing organisms. Under normal physiological conditions a balance between these species and the body’s anti-oxidant defenses exists. However, certain conditions can increase the production of Reactive Oxygen Species (ROS) such as the superoxide ion (O2-) and the hydroxyl ion (OH-).This can disrupt the natural balance and lead ultimately to oxidative stress. (see figure 1)

How do cells defend themselves?

Superoxide dismutase (SOD), along with catalase and glutathione peroxidase, form the front line of the body’s antioxidant enzyme defenses.The superoxide anion is the starting point of the cascade of reactions of free radical production. SOD, dubbed the “enzyme of life” on discovery in 1968, is the first antioxidant mobilized by the cell as defense against oxidative stress. The enzyme reacts with the superoxide ion and turns it into hydrogen peroxide (H2O2).(see figure 2) This is then catabolised by catalase and glutathione peroxidase to produce molecular oxygen (O2) and water (H2O).These antioxidant enzymes have a distinct advantage over the antioxidants consumed from the diet or nutritional supplements, like the vitamins A, C, and E, carotenoids, and thiols since the enzymes are biological catalysts, rapidly and repeatedly reducing reactive oxygen species without being consumed themselves. Like most other protective mechanisms in the body, the production of SOD decreases with age, while a cell’s susceptibility to oxidants increases, putting the cells under increasing oxidative stress.

Oral administration

Oral administration (see figure 4) of SOD and the other antioxidant enzymes present in many plant extracts is, under normal conditions, not effective. During passage through the gastrointestinal pathway the enzyme is denatured (deactivated) rendering it ineffective as an antioxidant. However, studies have shown that combining SOD with a wheat gliadin biopolymer system temporarily protects the SOD during its passage through the gastro-intestinal tract. One explanation of this efficiency was presented by Clemente et al. who showed that gliadin increases the permeability of the intestinal wall by promoting the release of a zonulin, thereby allowing the transport of the macromolecule SOD across the intestinal barrier.

The combination of SOD extracted from cantaloupe melon (Cucumis melo L.C.) with the wheat gliadin biopolymer (GliSODin®) significantly improves (see figure 5) the delayed release of SOD as evidenced in vitro by the progressive increase of its activity in a medium mimicking the digestive conditions. Vouldoukis et al. have shown ex vivo that prime activation of macrophages isolated from rodents with interferon-gamma (INF-gamma) subsequently challenged with IgGl/anti-IgG1 immune complexes leads to the significant production of superoxide anions. This production may be regulated, in a dose-dependent manner, in macrophages originating from rodents previously supplemented with GliSODin®. These results prove the potent in vivo activation of antioxidant activities made by the SOD-containing melon extract/gliadin biopolymer combination.

An important proof of concept in vivo study by Vouldoukis et al. using Balb/c mice receiving the SOD melon extract orally, either alone or combined with wheat gliadin (GliSODin®) for 28 weeks showed that only the gliadin-SOD complex resulted in a significant increase in circulating antioxidant levels.At the end of the study, the animals supplemented with GliSODin® had significantly lower levels of oxidative- stress induced DNA damage. Furthermore, the researchers found lower levels of apoptotic (dead) cells in the spinal fluid of the swine, thus showing a marked protective benefit.

The enzymatic activity of oral free SOD in the body is mainly to totally destroyed within few minutes, despite the source, and can so not promote the production of the SOD cascade by the cells (incl. endogenous SOD, gluthatione peroxidase and catalase) and the related expected optimal activities. For this reason, usual studies based on free SOD cannot prove the efficacy, or at an incredibly high use (in-vivo)

GliSODin® multiple health benefits have been demonstrated in human clinical studies :


• Protection of cellular DNA subjected to intense oxidative stress induced by pure oxygen in a hyperbaric chamber, with comet assay cell nucleous damage control (20 patients study)
• Increase of the MED (resistance to UV induced erythema or redness), and redness resolved more quickly, Skin’s protection against UV rays (50 patients study)
• Help prepare the skin for sun exposure and improved tanning speed and quality (150 patients study)
• Regulation of inflammation and decreases oxidative stress (35 patients)
• Significant decline in lactic acid levels (patients treated with GliSODin® for 4 weeks before strenuous exercise)Dose : 250mg to 2 x 250mg a day


Gontran Gaillot